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Test and treat for feline Urinary Tract Infection (UTI).
99% of cats who develop a cat litter box problem have a feline UTI. At the first sign of abnormal or non-litter box use, get your cat to the vet for a quick diagnosis and cure.
The longer your cat suffers from a feline UTI, the longer it will take to get her back into good cat litter box habits again.